+49 30 9210765-50

Scientific Publications


C. Lang (2018)
Lactobacillus – Mikrobe des Jahres. Lactobacillus – Alleskönner für die Gesundheut?
BioSpektrum 24 (1.18): 23-26


C. Holz, J. Benning, M. Schaudt, A. Heilmann, J. Schultchen, D. Goelling, C. Lang (2017)
Novel bioactive from Lactobacillus brevis DSM17250 to stimulate the growth of
Staphylococcus epidermidis: a pilot study

Beneficial Microbes. 2017 Feb 7;8(1):121-131.


R. Pörtner, R. Faschian, D. Goelling (2016)
Fermentation of Lactic Acid Bacteria: State of the Art and New Perspectives.
L. Hilterhaus, A. Liese, U. Kettling, G. Antranikian (Editor)
Applied Biocatalysis: From Fundamental Science to Industrial Applications.
ISBN 978-3-527-33669-2, WILEY-Verlag, August 2016,
chapter 14, pages 317-337


A. Patzschke, M. Steiger, C. Holz, C. Lang, D. Mattanovich, M. Sauer (2015)
Enhanced glutathione production by evolutionary engineering of Saccharomyces cerevisiae strains.
Biotechnology Journal 10

F. Glauche, G. T. John, S. Arain, A. Knepper, A. Neubauer, D. Goelling, C. Lang, N. Violet, R. King, P. Neubauer (2015)
Toward Microbioreactor Arrays: A Slow-Responding Oxygen Sensor for Monitoring of Microbial Cultures in Standard 96-Well Plates.
Journal of Laboratory Automation 1-9 2015


C. Holz, A. Busjahn, H. Mehling, S. Arya, M. Boettner, H. Habibi, C. Lang (2014)
Significant Reduction in Helicobacter pylori Load in Humans with Non-viable Lactobacillus reuteri DSM17648: A Pilot Study.
Probiotics & Antimicro. Prot. 7: 91-100


C. Holz, C. Alexander, C. Balcke, M. Moré, A. Auinger, M. Bauer, L. Junker, J. Grünwald, C. Lang, M. Pompejus (2013)
Lactobacillus paracasei DSMZ16671 Reduces Mutans Streptococci: A Short-Term Pilot Study.
Probiotics & Antimicro. Prot. 5:259-263


G. Shin, M. Veen, U. Stahl, C. Lang (2012)
Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
Yeast 29(9): 371-383


B. Lange-Asschenfeld, D. Marenbach, C. Lang, A. Patzelt, M. Ulrich, A. Maltusch, D. Terhorst, E. Stockfleth, W. Sterry, J. Lademann (2011)
Distribution of bacteria in the epidermal layers and hair follicles of the human skin.
Skin Pharmacol Physiol. 24: 305-311

K. Baumann, N. Adelantado, C. Lang, D. Mattanovich, P. Ferrer (2011)
Protein trafficking, ergosterol biosynthesis and membrane physics impact recombinant protein secretion in Pichia pastoris.
Microb Cell Fact. 10:93.

A.M. Raab, V. Hlavacek, N. Bolotina, C. Lang (2011)
Shifting the Fermentative/Oxidative Balance in Saccharomyces cerevisiae by Transcriptional Deregulation of the Snf1 Upstream Activating Kinase Sak1p.
Appl Environ Microbiol 77: 1981-1989

A. M. Raab, C. Lang (2011)
Oxidative versus reductive succinic acid production in the yeast Saccharomyces cerevisiae.
Bioengineered Bugs 2:1-4


A. M. Raab, G. Gebhardt, N. Bolotina, D. Weuster-Botz, C. Lang (2010)
Metablic Engineering of Saccharomyces cerevisiae for the biotechnological production of succinic acid.
Metabolic Engineering, November 2010, Pages 518-525

J.M. Tanzer, A. Thompson, C. Lang, L. Hareng, A. Garner, A. Reindl, M. Pompejus (2010)
Caries Inhibition by and Safety of Lactobacillus paracasei DSMZ16671.
J Dent Res. 89, 921-926

C. Lang, M. Böttner, C. Holz, M. Veen, M. Ryser, A. Reindl, M. Pompejus, J. M. Tanzer (2010)
Specific Lactobacillus/Mutans Streptococcus Co-aggregation.
J Dental Res 89, 175-179

S.P. Riechers, U. Stahl, C. Lang (2010)
Endocytic uptake of fluorescence labelled DNA in yeast.
J Basic Microbiol. 50, 83-89

T. Lautz, U. Stahl, C.Lang (2010)
The human c-fos and TNFα AU-rich elements show different effects on mRNA abundance and protein expression depending on the reporter in the yeast Pichia pastoris.
Yeast 27, 1-9


S.P. Riechers, U. Stahl, C. Lang (2009)
Defects in intracellular trafficking and endocytic/vacuolar acidification determine the efficiency of endocytotic DNA uptake in yeast.
Journal of Cellular Biochemistry 106, 327-336


Martín Granados, C., Riechers, S.P., Stahl, U., Lang, C. (2008)
Absence of See1p, a widely conserved Saccharomyces cerevisiae protein, confers both deficient heterologous protein production and endocytosis.
Yeast 25, 871-877

B. Gasser, M. Saloheimo, U. Rinas, M. Dragosits, E. Rodriguez-Carmona, K. Baumann, M. Giuliani, E. Parrilli, P. Branduardi, C. Lang, D. Porro, P. Ferrer, M. L. Tutino, D. Mattanovich, A. Villaverde (2008)
Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview
Microbial Cell Factories 7: 11

T.M. Bandeiras, R.C. Hillig, P.M. Matias, U. Eberspaecher, J. Fanghänel, M. Thomaz, S. Miranda, K. Crusius, V. Pütter, P. Amstutz, M. Gulotti-Georgieva, H.K. Binz, C. Holz, A.A.P. Schmitz, C. Lang, P. Donner, U. Egner, M.A. Carrondo, B. Müller-Tiemann (2008)
Crystal structure of Wild-Type Plk-1 Kinase Domain in Complex with a Selective DARPin.
Acta Crystallogr D Biol Crystallogr. 64: 339-353

B. Gasser , M. Saloheimo , U. Rinas , M. Dragosits , E. Rodriguez-Carmona , K. Baumann , M. Giuliani , E. Parrilli, P. Branduardi , C. Lang , D. Porro , P. Ferrer , M. Tutino , D. Mattanovich  and A. Villaverde (2008)
Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview.
Microbial Cell Factories 7:11


M. Boettner, C. Steffens, C. von Mering, P. Bork, U. Stahl, C. Lang (2007)
Sequence-based factors influencing the expression of heterologous genes in the yeast Pichia pastoris--A comparative view on 79 human genes.
J Biotechnol. 130: 1-10

T. Hornbogen, S.P. Riechers, B. Prinz, J. Schultchen, C. Lang, S. Schmidt, C. Mügge, S. Turkanovic, R.D. Süssmuth, E. Tauberger, R. Zocher (2007)
Functional Characterization of the Recombinant N-Methyltransferase Domain from the Multienzyme
Enniatin Synthetase.

Chembiochem. 18: 1048-1054

C. Lang (2007)
Saccharomyces cerevisiae: a microbial eukaryotic expression system
In: Expression Systems, The Methods Express Series (M.R. Dyson, Y. Derocher, eds.), Scion Publishing Limited

C. Lang (Co-author) (2007)
Cologne Paper: En Route to the Knowledge-based Bio-Economy.
European Commission, Brüssel

T. Achstetter, G. Klöck, C. Lang
Ein Modell für eine raschere und gezieltere berufliche Eingliederung von Absolventen der neuen Bachelorstudiengänge.
Die neue Hochschule 48: 1


A.R. Aricescu, R. Assenberg, R.M. Bill, D. Busso, V.T. Chang, S.J. Davis, A. Dubrovsky, L. Gustafsson, K. Hedfalk,

U. Heinemann, I.M. Jones, D. Ksiazek, C. Lang, K. Maskos, A. Messerschmidt, S. Macieira, Y. Peleg, A. Perrakis, A.

Poterszman, G. Schneider, T.K. Sixma, J.L. Sussman, G. Sutton, N.Tarboureich, T. Zeev-Ben-Mordehai, E.Y. Jones

Eukaryotic expression: developments for structural proteomics.
Acta Crystallogr D Biol Crystallogr. 62: 1114-24

B. Neukamm, A. Weimann, S. Wu, M. Danevad, C. Lang, R. Geßner (2006)
Novel two-stage screening procedure leads to the identification of a new class of transfection enhancers.
J. Gene Med 8: 745-53

T. Achstetter, G. Klöck, C. Lang (2006)
transcript 1-2: 59

C. Holz, C. Lang (2006)
Expression of cDNA in yeast.
Cell Biology Chapter 8: 57-62
Elsevier Science (USA)


M. Veen, C. Lang (2005)
Interactions of the ergosterol biosynthetic pathway with other lipid pathways.
Biochemical Society Transactions 33: 1178-1181

A. P. Turnbull, D. Kümmel, B. Prinz, C. Holz, J. Schultchen, C. Lang, F. H. Niesen, K.-P. Hofmann, H. Delbrück, J. Behlke, E.-C. Müller, E. Jarosch, T. Sommer, U. Heinemann (2005)
Structure of Palmitoylated BET3: Insights into TRAPP Complex Assembly and Membrane Localization.
EMBO Journal 24: 875-884

C. Lang, H. Zorn (2005)
Health off the shelf.
In: Biotechnology 2020, European Commission


B. Prinz, J. Schultchen, R. Rydzewski, C. Holz, M. Boettner, U. Stahl, C. Lang (2004)
Establishing a versatile fermentation and purification procedure for human proteins expressed in the yeasts Saccharomyces cerevisiae and Pichia pastoris for structural genomics.
J. Struct. Funct. Genomics 5: 29-44

C. Lang (2004)
Gesunder Genuss - Lebensmittel statt Pillen.
Lebensmittel Industrie LVT 7/8: 52-53

C. Lang, H. Zorn (2004)
Der Supermarkt als Apotheke.
In: Biotechnologie 2020. DECHEMA e.V.

C. Lang (2004)
Ernährung nach den Genen
Lebensmittel Industrie LVT 9/10: 52-53

C. Holz, C. Lang (2004)
High Throughput Expression in Microplate Format in Saccharomyces cerevisiae.
In: Methods in Molecular Biology, vol. 267: Recombinant Gene Expression: Reviews and Protocols, Second Edition, p. 267-276
Edited by: P. Balbas and A. Lorence, Humana Press Inc., Totowa, NJ

M. Böttner, C. Lang (2004)
High throughput expression in microplate formate in Pichia pastoris.
In: Methods in Molecular Biology, vol. 267: Recombinant Gene Expression: Reviews and Protocols, Second Edition, p. 277-286
Edited by: P. Balbas and A. Lorence, Humana Press Inc., Totowa, NJ

B. Prinz, C. Lang (2004)
Gene Regulation in Yeast.
Mycota II, Chapter 8, Springer Verlag 


M. Veen, C.Lang (2003)
Production of lipid compounds in the yeast Saccharomyces cerevisiae.
Appl. Microbiol. Biotechnol. 63: 635-646

M. Veen, U. Stahl, C. Lang (2003)
Combined overexpression of genes of the ergosterol biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
FEMS Yeast Research 4: 87-95

C. Holz, B. Prinz, N. Bolotina, V. Sievert, K. Büssow, B. Simon, U. Stahl, C. Lang (2003)
Establishing the yeast Saccharomyces cerevisiae as a system for expression of human proteins on a proteome-scale.
J. Struct. Funct. Genomics 4: 97-108

B. Prinz, U. Stahl, C. Lang, (2003)
Intracellular transport of a heterologous membrane protein, the human transferrin receptor, in Saccharomyces cerevisiae.
Internat. J. Microbiol. 6: 49-55


B. Neukamm, U. Stahl, C. Lang (2002)
Endocytosis is involved in DNA uptake in yeast.
Biochim. Biophys. Acta 1572: 67-76

M. Boettner, B: Prinz, C. Holz, U. Stahl, C. Lang (2002)
High-throughput screening for expression of heterologous proteins in the yeast Pichia pastoris.
J. Biotechnology 99: 51-62

C. Holz,, O. Hesse, N. Bolotina, U. Stahl, C. Lang, (2002)
A micro-scale process for high-throughput expression of cDNAs in the yeast Saccharomyces cerevisiae.
Prot. Expression Purif. 25: 372-378

T. Platzek, R. Stahlmann, M. Wegener, C. Lang (2002)
Allergene in kosmetischen Mitteln, Waschmitteln, Textilien.
Mitt. Lebensm. Hyg. 93: 591-616


T. Platzek, T. Wannack, R. Stahlmann, K. Riecke, C. Lang, H. Höcker (2001)
Textilfarbstoffe - Regulation und experimentelle Studien.
Bundesgesundheitsbl. - Gesundheitsforsch. - Gesundheitsschutz 44: 695-704

C. Lang, P. Umbach (2001)
Structural Genomics for Drug Design.
Screening 2: 54-57

C. Lang (2001)
Die Proteinstrukturfabrik - Strukturaufklärung für die Wirkstoffforschung im Hochdurchsatzverfahren.
BIOforum 24: 290-292


C. Lang, H. Dörnenburg (2000)
Perspectives in the biological function and the technological application ofpolygalacturonases (Minireview).
Appl. Microbiol. Biotechnol. 53: 366-375


T. Polakowski, R. Bastl, U. Stahl, C. Lang (1999)
Enhanced sterol-acyl transferase activity promotes sterol accumulation in Saccharomyces cerevisiae.
Appl. Microbiol. Biotechnol. 53: 30-35

T. Platzek, C. Lang, G. Grohmann, U.-S. Gi, W. Baltes (1999)
Formation of a carcinogenic aromatic amine from an azo dye by human skin bacteria in vitro.
Human Experiment. Toxicol. 18: 552-559

U. Marx, T. Polakowski, T. Pomorski, C. Lang, H. Nelson, A. Herrmann (1999)
Protein-mediated rapid transbilayer movement of fluorescent phospholipid analogues in the plasma membrane of endocytosis-deficient yeast cells.
Eur. J. Biochem. 263: 254-263

C. Lang, T. Polakowski, B. Prinz, M. Böttner, U. Stahl (1999)
Heterologous membrane proteins in Saccharomyces cerevisiae: intracellular
targeting of bacterio-opsin.
in: Endocytobiology VII (E. Wagner et al., Eds.), University of Geneva, pp. 397-405


H.J. Terng, R. Geßner, H. Fuchs, U. Stahl, C. Lang (1998)
Human transferrin receptor is active and plasma membrane-targeted in yeast.
FEMS Microbiol. Letters 160: 61-67

T. Polakowski, U. Stahl, C. Lang (1998)
Overexpression of a cytosolic HMG-CoA reductase in yeast leads to squalene accumulation.
Appl. Microbiol. Biotechnol. 49: 66-71


C. Lang, C. Göllnitz, M. Popovic, U. Stahl (1997)
Optimisation of fungal polygalacturonase synthesis by Saccharomyces cerevisiae in fed-batch culture.
Chem. Engineer. J. 65: 219-226


C. Lang (1996)
Glutathion aus Saccharomyces cerevisiae: Stamm¬verbesserung und verfahrenstechnische Optimierung.
VH Hefetagung, Proceedings.


C. Lang, A.C. Looman (1995)
Efficient expression and secretion of Aspergillus niger RH5344 polygalacturonase in Saccharomyces cerevisiae.
Appl. Microbiol. Biotechnol. 44: 147-156

C. Lang-Hinrichs (1995)
Gene regulation in yeast.
Mycota II, Genetics and Biotechnology (Kück, U., ed.), pp. 141-153
Springer Verlag, Berlin


C. Lang-Hinrichs, I. Queck, G. Büldt, U. Stahl, V. Hildebrandt (1994)
The archaebacterial membrane protein bacterio-opsin is expressed and N-terminally processed in the yeast Saccharomyces cerevisiae.
Mol. Gen. Genet. 244: 183-188

H. Dörnenburg, C. Lang-Hinrichs (1994)
Genetic engineering in food biotechnology.
Chemistry and Industry 13: 506-510


C. Lang-Hinrichs (1993)
Recombinant yeasts for producing foods and food ingredients.
Food Ingredients Europe Conference Proceeding, pp. 229-231, Expoconsult Publishers, Maarsen, The Netherlands

C. Lang-Hinrichs (1993)
Transformation of the baker's yeast Saccharomyces cerevisiae with plasmids carrying bacterial neomycin resistance genes.
in: The Ohio Science Workbook: BIOTECHNOLOGY. The Ohio Academy of Science, Columbus, Ohio U.S.A., pp. 95-97


C. Lang-Hinrichs, J. Hinrichs (1992)
Recombinant yeasts in food and food manufacture — possibilities and perspectives.
AGRO Industry HI-TECH 5: 12-18


C. Lang-Hinrichs, C. Dössereck, I. Fath, U. Stahl (1990)
Use of the Tn903 neomycin-resistance gene for promoter analysis in the fission yeast Schizosaccharomyces pombe.
Curr. Genet. 18: 511-551


C. Lang-Hinrichs, D. Berndorff, C. Seefeldt, U. Stahl (1989)
G418 resistance in the yeast Saccharomyces cerevisiae: comparison of the neomycin resistance genes from Tn5 and Tn903.
Appl. Microbiol. Biotechnol. 30: 388-394


C. Lang-Hinrichs, U. Stahl (1987)
Cloning vectors of mitochondrial origin in eukaryotes.
Methods in Enzymology (eds R. Wu, L. Grossman) Vol.153, pp. 366 - 382
Academic Press, San Diego, New York


K. Esser, U. Kück, C. Lang-Hinrichs, P. Lemke, H.D. Osiewacz, U. Stahl, P.Tudzynski (1986)
Plasmids in Eukaryotes.
Springer Verlag, Berlin

C. Lang-Hinrichs, U. Stahl (1986)
Autonom replizierende Vektoren für Pilze.
BioEngineering 4: 22 - 31

U. Stahl, C. Lang-Hinrichs (1986)
Mitochondriale DNS.
in: Jahrbuch Biotechnologie 1986/87 (Herausgeber: W. Crueger, K. Esser, P. Präve, M. Schlingmann, R. Thauer, F. Wagner), Carl Hanser Verlag, München, Wien


K.Esser, C. Lang-Hinrichs (1983)
Molecular cloning in heterologous systems.
Adv. Biochem. Eng. Biotechnol. 26: 143-173


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